Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?
    Treatment 5/22/2024

    From the encyclopedia
    Clascoterone →

    Topical androgen-receptor blocker, approved as an acne cream

    Pyrilutamide →

    Experimental topical anti-androgen, also known as KX-826

    GT20029 →

    Experimental topical drug designed to break down androgen receptors

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💧 Clascoterone (topical)
    💧 Pyrilutamide (topical)
    💧 GT20029 (topical)
    💧 RU58841 (topical)
    💧 Ketoconazole (topical) 2% 2x weekly
    the tone is 😐 neutral.

    Other terms

    The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.
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    5 / 5 results

      community Most Promising Future Hair Loss Treatments In 2026

       83 upvotes 2 weeks ago
      Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

      community Clascoterone study going on right now

       351 upvotes 2 years ago
      A user is participating in a phase 3 trial for Clascoterone, a topical acne medication that may stimulate hair growth, and will share results after 6 months. They will have a section of their hair shaved and marked with a tattoo for the study.

      community Is there any new drug that looks promising ?

       26 upvotes 2 years ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community Currently Trending Twitter Post: Clascoterone Hailed as New Cure

       1897 upvotes 9 months ago
      Clascoterone is being discussed as a promising new hair loss treatment, showing significant improvement in trials. Despite this, skepticism persists about its effectiveness, cost, and side effects, with some users preferring minoxidil and finasteride.

      community What new hair-loss treatments actually look exciting right now (Oct 2025)

       171 upvotes 11 months ago
      New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.

    Related Research

    6 / 6 results

      research Androgens/Androgen Receptor in the Management of Skin Diseases

      1 citations , January 2022 in “Journal of Biosciences and Medicines”
      This review discusses the roles of androgens and androgen receptor in skin diseases like acne and hirsutism, and highlights the promise of antiandrogen drugs, reporting no new clinical findings.

      research Androgenetic alopecia - a literature review

      June 2025 in “Journal of Education Health and Sport”
      This review highlights that while finasteride and minoxidil effectively treat androgenetic alopecia, emerging options like dutasteride, mesotherapy, androgen blockers, and red LED therapy show promising results, especially when used in combination, though further research is needed for standardization and safety confirmation.

      research A decade of progress in androgenetic alopecia management: Emerging therapies and multimodal strategies

      December 2025 in “IP Indian Journal of Clinical and Experimental Dermatology”
      This review reports that the treatment of androgenetic alopecia is shifting from single therapies to personalized, multimodal approaches incorporating both traditional and emerging pharmacologics, regenerative strategies, nutraceuticals, cosmeceuticals, and device-based interventions, with combination regimens showing improved outcomes.

      research The Hormonal Background of Hair Loss in Non-Scarring Alopecias

      February 2024 in “Biomedicines”
      This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.

      research Hormonal therapies for acne

      26 citations , October 2016 in “Clinics in Dermatology”
      This article discusses various hormonal therapies for acne and provides practical treatment guidelines for managing hormonally related acne, but it reports no new research findings.