The Hormonal Background of Hair Loss in Non-Scarring Alopecias

    February 2024 in “ Biomedicines
    Barbara Owecka, Anna Tomaszewska, Krzysztof Dobrzeniecki, Maciej Owecki
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    TLDR Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.
    The review "The Hormonal Background of Hair Loss in Non-Scarring Alopecias" discusses the role of various hormones in hair loss. Androgens like dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS) can cause hair follicle miniaturization and hair loss. Estrogen deficiency, often seen during menopause, can also lead to hair loss. Thyroid hormones and dysfunctions are linked with common types of alopecia, including telogen effluvium (TE), alopecia areata (AA), and androgenetic alopecia. Stress hormones like corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol can induce hair loss. Treatments include 5-alpha-reductase inhibitors (finasteride, dutasteride), spironolactone, bicalutamide, estrogens, and others. The review also mentions that hair loss can be a sign of underlying endocrine disorders and recommends checking the thyroid profile in patients with hair loss.
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