The Hormonal Background of Hair Loss in Non-Scarring Alopecias

    February 2024 in “ Biomedicines
    Barbara Owecka, Anna Tomaszewska, Krzysztof Dobrzeniecki, Maciej Owecki
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    TLDR Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.
    The review "The Hormonal Background of Hair Loss in Non-Scarring Alopecias" discusses the role of various hormones in hair loss. Androgens like dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS) can cause hair follicle miniaturization and hair loss. Estrogen deficiency, often seen during menopause, can also lead to hair loss. Thyroid hormones and dysfunctions are linked with common types of alopecia, including telogen effluvium (TE), alopecia areata (AA), and androgenetic alopecia. Stress hormones like corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol can induce hair loss. Treatments include 5-alpha-reductase inhibitors (finasteride, dutasteride), spironolactone, bicalutamide, estrogens, and others. The review also mentions that hair loss can be a sign of underlying endocrine disorders and recommends checking the thyroid profile in patients with hair loss.
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      community A lot of blood tests that I have done until now (Mainly Hormones).

      in Finasteride/Dutasteride  5 upvotes 4 years ago
      The user shared their experience with hair loss treatments, including oral and topical Finasteride and Minoxidil, and detailed various blood test results to track hormonal changes. They noted that while DHT levels initially decreased with topical Finasteride, they later increased, but they observed positive results in hair growth.

      community risks with finasteride and dutasteride

      in Research/Science  143 upvotes 4 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community I hope ET-02 or PP405 will be released in the next 4-5 years

      in Product  15 upvotes 4 months ago
      PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

      community My Testosterone results before and after Finasteride

      in Update  148 upvotes 4 years ago
      Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

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