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GlossaryDehydroepiandrosterone (DHEA)

hormone produced by adrenal glands, precursor to sex hormones

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands, which are located above the kidneys. It serves as a precursor to male and female sex hormones, including testosterone and estrogen. DHEA levels naturally decline with age and are sometimes supplemented to address various health issues, such as adrenal insufficiency, depression, and certain autoimmune diseases.

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A Randomized Trial of Oral DHEA Treatment for Sexual Function, Well-Being, and Menopausal Symptoms in Postmenopausal Women with Low Libido

research A Randomized Trial of Oral DHEA Treatment for Sexual Function, Well-Being, and Menopausal Symptoms in Postmenopausal Women with Low Libido

48 citations , July 2009 in “The Journal of Sexual Medicine”

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

research The Safety of 52 Weeks of Oral DHEA Therapy for Postmenopausal Women

46 citations , May 2009 in “Maturitas”

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

research DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms

31 citations , December 2016 in “Anais Brasileiros de Dermatologia”

The document reviewed the role of transforming growth factor-beta 1 (TGFβ1) in promoting fibrosis and its interaction with peroxisome proliferator-activated receptor (PPAR), which negatively regulates fibrotic events. Dehydroepiandrosterone (DHEA), an immunomodulatory hormone crucial for PPAR functions, was noted to be reduced in fibrotic processes. The study highlighted that while scarring alopecia often occurs during a period of decreased DHEA production in females, there was no existing literature directly linking DHEA reduction to the fibrogenic process in frontal fibrosing alopecia. The article aimed to explore the fibrogenic activity of TGFβ1, its regulation by PPAR, and its connection with DHEA in the context of frontal fibrosing alopecia.

Methodology and Challenges to Recruitment to a Randomized, Double-Blind, Placebo-Controlled Trial of Oral DHEA in Postmenopausal Women

research Methodology and Challenges to Recruitment to a Randomized, Double-Blind, Placebo-Controlled Trial of Oral DHEA in Postmenopausal Women

9 citations , November 2008 in “Journal of Womens Health”

Researchers had trouble finding enough participants for a trial on DHEA's effects on postmenopausal women's sexual desire.

Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

research Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

9 citations , February 2020 in “International Journal of Endocrinology”

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

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community Female AGA - Low Cortisol/Low DHEA

in Female 6 upvotes 2 years ago

Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

community Hair loss - Blood work (High DHEAS)

in Research/Science 7 upvotes 3 years ago

A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Blood test 3 days after finasteride. Is it ok?

in Finasteride/Dutasteride 3 upvotes 1 year ago

A user asked if taking a blood test 3 days after starting finasteride would affect the results for Estradiol, FSH, SHBG, Progesterone, and DHEA-S. The conversation is about the timing of blood tests after beginning finasteride treatment.

community My Experience and a Discourse on "DUPA"

in Treatment 9 upvotes 1 year ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

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