here is why isotretinoin might cause hair loss and maybe why dupa happens.
Research/Science 6/30/2023
isotretinoin DHT DHEAS topical antiandrogens RU58841 pyrilutamide PPAR-y expression pioglitazone telogen effluvium 5AR inhibitors finasteride oestrodial aromatase keratosis pilaris keratin Accutane Dihydrotestosterone Dehydroepiandrosterone sulfate Propecia Estrogen
Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.
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