175 citations
,
  April 1982   in “Journal of The American Academy of Dermatology”    Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.  
     
           126 citations
,
  October 1983   in “Journal of The American Academy of Dermatology”    Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.  
     
           121 citations
,
  June 2010   in “Australasian Journal of Dermatology”    Most people on isotretinoin had chapped lips, but only a few stopped the medicine due to side effects.  
     
           66 citations
,
  January 2017   in “Acta dermato-venereologica”    Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.  
               58 citations
,
  November 2018   in “Cochrane library”    Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.