Advice on the Safe Introduction and Continued Use of Isotretinoin in Acne in the U.K. 2010
May 2010
in “
British Journal of Dermatology
”
TLDR Isotretinoin is effective for severe acne but requires careful monitoring for side effects, especially in women who could become pregnant.
The document provided guidance on the safe use of isotretinoin for treating severe acne in the U.K. in 2010, emphasizing its effectiveness and potential side effects, such as teratogenicity and mood changes. It stressed the importance of the Pregnancy Prevention Programme (PPP) to prevent birth defects, requiring effective contraception and regular pregnancy testing for women of childbearing potential. Concerns about mood changes, including depression, were addressed, with recommendations for careful psychiatric screening and monitoring, especially for those with a history of psychiatric disorders. The guidelines advised that isotretinoin be prescribed by consultant dermatologists, with strict adherence to monitoring protocols, including liver function and lipid tests, to ensure patient safety and compliance.
