Advice on the Safe Introduction and Continued Use of Isotretinoin in Acne in the U.K. 2010
May 2010
in “
British Journal of Dermatology
”
TLDR Isotretinoin is effective for severe acne but requires careful monitoring for side effects, especially in women who could become pregnant.
The document provided guidance on the safe use of isotretinoin for severe acne in the U.K. in 2010, emphasizing its effectiveness and the need to manage side effects, particularly teratogenicity in women of childbearing potential. It recommended the Pregnancy Prevention Programme (PPP) to prevent pregnancy during treatment due to the high risk of birth defects. Concerns about mood changes, including depression, were addressed, though evidence was conflicting. Regular monitoring of liver function and lipid levels was advised, and isotretinoin was contraindicated in pregnancy and hyperlipidaemia. The document stressed that isotretinoin should be prescribed by experienced dermatologists, with specific protocols for prescribing and monitoring, and highlighted the importance of monitoring psychiatric health in patients, especially those with a history of psychiatric disorders.
