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GlossaryTeratogenicity

ability of a substance to cause birth defects

Teratogenicity refers to the ability of a substance to cause birth defects or developmental malformations in a developing embryo or fetus. This can occur when a pregnant woman is exposed to certain drugs, chemicals, or environmental factors that interfere with normal fetal development, potentially leading to physical or functional abnormalities in the newborn.

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research Infertility and Teratogenicity After Paternal Exposure to Systemic Dermatologic Medications: A Systematic Review

18 citations, October 2018 in “Journal of The American Academy of Dermatology”

Some skin medications can harm male fertility, but they don't seem to cause birth defects from father's exposure.

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

66 citations, January 2017 in “Acta dermato-venereologica”

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

research Use of Chemotherapy During Human Pregnancy

724 citations, April 2004 in “Lancet Oncology”

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

research British Association of Dermatologists Guidelines on the Efficacy and Use of Acitretin in Dermatology

136 citations, April 2010 in “British Journal of Dermatology”

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

research Isotretinoin Treatment of Acne and Related Disorders: An Update

126 citations, October 1983 in “Journal of The American Academy of Dermatology”

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.