Valproic Acid Teratogenicity in Whole Embryo Culture Is Not Prevented by Zinc Supplementation

Zinc supplementation caused significant hair shedding for the user, who had been successfully managing hair loss with finasteride, minoxidil, RU58841, and microneedling. The user discontinued zinc after noticing no libido increase and believes the hair loss was due to zinc's interaction with other minerals or hormonal changes.

A 20-year-old male is concerned that zinc might reduce the effectiveness of finasteride for hair loss, as zinc is known to increase DHT levels. Users suggest that zinc, at certain doses, has anti-androgenic properties and is unlikely to negatively impact finasteride's efficacy.

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

Taking zinc may reduce side effects of finasteride, such as gyno, by preventing testosterone from converting to estrogen. Some users report improved symptoms with zinc, but excessive intake can cause issues like copper deficiency or stomach problems.

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

Zinc supplements may slightly increase DHT by affecting testosterone conversion, but are generally beneficial for health. A 15mg Zinc to 1mg Copper ratio is recommended.