Effect of Antiandrogens on Valproic Acid-Induced Neurodevelopmental Changes in Rats

July 2023 in “ Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ ”

Hanan S.M. Farghaly, Marwa F. Bakr, HODA SAYED, Israa El-Sayed Mohamed Ashry

antiandrogens valproic acid flutamide finasteride androgens VPA

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Studysummary The research investigated the effects of antiandrogens on neurodevelopmental milestones in rats exposed to valproic acid during pregnancy, finding that while valproic acid delayed sensorimotor reflexes, it didn't impact physical development milestones, and antiandrogens partially mitigated these delays.

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This study investigated the effects of antiandrogens on neurodevelopmental changes induced by valproic acid (VPA) in rats. Pregnant rats were injected with VPA, and their offspring were divided into seven groups, with some receiving antiandrogens like flutamide and finasteride. The results showed that VPA caused delays in sensorimotor reflexes but did not affect physical development. Antiandrogens improved developmental milestones, suggesting that androgens play a role in VPA-induced neurodevelopmental issues.

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