Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats

September 2013 in “ The International Journal of Neuropsychopharmacology ”

Laura Mòdol, Caty Casas, Xavier Navarro, Anna Llidó, Monique Vallée, Marc Pallarès, Sònia Darbra

Studysummary This study found that neonatal finasteride treatment in male rats altered hippocampal GABAA receptor subunit expression and led to increased anxiety-like behavior in response to progesterone in adulthood. Our plain-language summary of this paper — not a Tressless recommendation.

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This study found that neonatal administration of allopregnanolone enhances, while finasteride suppresses, the effects of adult intrahippocampal pregnenolone sulphate on rat locomotor activity in an open field test.

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research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

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