Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats

    September 2013 in “ The International Journal of Neuropsychopharmacology ”
    Laura Mòdol, Caty Casas, Xavier Navarro … Sònia Darbra
    Studysummary This study found that neonatal finasteride treatment in male rats altered hippocampal GABAA receptor subunit expression and led to increased anxiety-like behavior in response to progesterone in adulthood.
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    Research cited in this study 9

    1. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    2. Alteration of Neonatal Allopregnanolone Levels Affects Exploration, Anxiety, Aversive Learning, and Adult Behavioral Response to Intrahippocampal Neurosteroids Behavioural Brain Research · 2012
    3. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors Journal of Neuroscience · 2011
    4. Interaction Between Early Postnatal Neurosteroid Manipulations and Adult Infusion of Neurosteroids Into CA1 Hippocampal Region on the Open Field Behavior Behavioural Brain Research · 2010
    5. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    6. Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration Neuroscience · 2008
    7. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    8. Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice Neuropharmacology · 2004
    9. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997

    Related research 4

    1. Respiratory Regulation by Steroids in Newborn Rats: A Sex-Specific Balance Between Allopregnanolone and Progesterone Receptors Experimental physiology · 2017
    2. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    3. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    4. Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration Neuroscience · 2008