Interaction Between Early Postnatal Neurosteroid Manipulations and Adult Infusion of Neurosteroids Into CA1 Hippocampal Region on the Open Field Behavior

October 2010 in “ Behavioural Brain Research ”

Sònia Darbra, Marc Pallarés

allopregnanolone pregnenolone sulphate finasteride neurosteroids hippocampus AlloP PregS

TLDR Early neurosteroid changes can alter adult brain function and behavior.

The study examined the effects of neonatal manipulation of allopregnanolone (AlloP) on adult neurosteroid infusions in the hippocampus and their impact on open field behavior in rats. It was observed that neonatal AlloP administration reduced the effects of adult AlloP infusions on locomotor activity but enhanced the effects of pregnenolone sulphate (PregS). Conversely, neonatal finasteride administration diminished the effects of both AlloP and PregS infusions in adulthood. These results indicated that early neurosteroid manipulations led to enduring neurobiological changes in the hippocampus, affecting adult behavior. The study included 81 male Wistar rats.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood

35 citations , September 2009 in “Psychoneuroendocrinology”

Early-life neurosteroid changes affect adolescent exploration and adult behavior.

research Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain

76 citations , July 2009 in “Neuroscience”

research Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone

123 citations , May 2009 in “Journal of Neuroscience”

In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.

research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

27 citations , May 2008 in “Neuroscience”

Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches

83 citations , January 2004 in “Pharmacology & Therapeutics”

Adjusting neurosteroid levels may help reduce alcohol withdrawal symptoms.

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

98 citations , April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

research Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment

26 citations , July 1995 in “Neurobiology of Aging”

Finasteride affects prostate weights and pituitary activity differently with age.

Similar Research

5 / 291 results

research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

27 citations , May 2008 in “Neuroscience”

Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

research Hormones and Absence Epilepsy

January 2017 in “Elsevier eBooks”

Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

82 citations , August 2006 in “Pharmacology, Biochemistry and Behavior”

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

research Molecular Basis of Androgen Action on Human Sexual Desire

12 citations , September 2017 in “Molecular and Cellular Endocrinology”

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

Interaction Between Early Postnatal Neurosteroid Manipulations and Adult Infusion of Neurosteroids Into CA1 Hippocampal Region on the Open Field Behavior

Research cited in this study

research Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood

research Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain

research Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone

research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

research Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment

Related Community Posts Join

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

community Checking in with my post-fin symptoms

community I quit Oral Finasterise over a year ago and here's what I've found

Similar Research

research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

research Hormones and Absence Epilepsy

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

research Molecular Basis of Androgen Action on Human Sexual Desire

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase