Interaction Between Early Postnatal Neurosteroid Manipulations and Adult Infusion of Neurosteroids Into CA1 Hippocampal Region on the Open Field Behavior

    October 2010 in “ Behavioural Brain Research ”
    Sònia Darbra, Marc Pallarés
    Studysummary This study found that neonatal administration of allopregnanolone enhances, while finasteride suppresses, the effects of adult intrahippocampal pregnenolone sulphate on rat locomotor activity in an open field test.
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    Research cited in this study 8

    1. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    2. Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain Neuroscience · 2009
    3. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone Journal of Neuroscience · 2009
    4. Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration Neuroscience · 2008
    5. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    6. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    7. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997
    8. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995