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GlossaryAllopregnanolone

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations, August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

research Allopregnanolone Mediates the Exacerbation of Tourette-Like Responses by Acute Stress in Mouse Models

25 citations, June 2017 in “Scientific reports”

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

research Allopregnanolone Promotes Proliferation and Differential Gene Expression in Human Glioblastoma Cells

25 citations, March 2017 in “Steroids”

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

research Role of Allopregnanolone Biosynthesis in Acute Stress-Induced Anxiety-Like Behaviors in Mice

19 citations, April 2017 in “Synapse”

Blocking allopregnanolone production in mice makes them more anxious after stress, but this can be reversed with a drug that mimics allopregnanolone.

research Respiratory Regulation by Steroids in Newborn Rats: A Sex-Specific Balance Between Allopregnanolone and Progesterone Receptors

17 citations, November 2017 in “Experimental physiology”

Breathing in newborn rats is affected differently by hormones based on their sex.

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community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 1 year ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 283 upvotes 3 months ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 1 year ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community A Summary of the Latest Research regarding PFS, and How Supplementing Allopregnanolone Might Protect Against It

in Chat 6 upvotes 1 year ago

Post Finasteride Syndrome (PFS) may result from epigenetic changes and gut microbiota alterations. Supplementing with Allopregnanolone might protect against these adverse effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 1 year ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

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