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    Glossary Allopregnanolone

    neurosteroid derived from progesterone that modulates brain activity

    Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

    Research 10 of 295

    1. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone Journal of Neuroscience · 2009 · 123 citations
    2. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology · 2015 · 110 citations
    3. Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain Pain · 2011 · 61 citations
    4. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    5. Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output Brain Research · 2002 · 52 citations
    6. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 43 citations
    7. Allopregnanolone and Induction of Endogenous Opioid Inhibition of Oxytocin Responses to Immune Stress in Pregnant Rats Journal of Neuroendocrinology · 2012 · 41 citations
    8. Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis Drug and Alcohol Dependence · 2008 · 35 citations
    9. Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats Frontiers in Behavioral Neuroscience · 2015 · 34 citations
    10. Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice Pharmacology Biochemistry and Behavior · 2009 · 29 citations
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    Community 10 of 21

    1. How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that Reddit · 31 May 2025
    2. How come dutasteride doesn't lower allopregnanolone, but finasteride does? Reddit · 8 Jan 2025
    3. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    4. Research and Question about Allopregnanolone, Multiple Sclerosis, TRT, and Finasteride Reddit · 7 Nov 2022
    5. Allopregnanolone deficiency by 5-ari inhibition (fin/dut users) Reddit · 11 Dec 2023
    6. Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight? Reddit · 22 May 2024
    7. So it turns out Post Finasteride Syndrome was never real? Reddit · 30 Jul 2024
    8. Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral. Reddit · 20 Jul 2024
    9. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    10. What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas Reddit · 25 Jun 2024
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