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    Glossary Allopregnanolone

    neurosteroid derived from progesterone that modulates brain activity

    Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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    Research 30 of 295

    1. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone Journal of Neuroscience · 2009 · 123 citations
    2. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology · 2015 · 110 citations
    3. Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain Pain · 2011 · 61 citations
    4. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    5. Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output Brain Research · 2002 · 52 citations
    6. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 43 citations
    7. Allopregnanolone and Induction of Endogenous Opioid Inhibition of Oxytocin Responses to Immune Stress in Pregnant Rats Journal of Neuroendocrinology · 2012 · 41 citations
    8. Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis Drug and Alcohol Dependence · 2008 · 35 citations
    9. Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats Frontiers in Behavioral Neuroscience · 2015 · 34 citations
    10. Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice Pharmacology Biochemistry and Behavior · 2009 · 29 citations
    11. Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus European Journal of Neuroscience · 2009 · 28 citations
    12. Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models Scientific reports · 2017 · 25 citations
    13. Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells Steroids · 2017 · 25 citations
    14. Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids Behavioural Brain Research · 2012 · 24 citations
    15. Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice Synapse · 2017 · 19 citations
    16. Neonatal neurosteroid levels are determinant in shaping adult prepulse inhibition response to hippocampal allopregnanolone in rats Psychoneuroendocrinology · 2013 · 18 citations
    17. Respiratory regulation by steroids in newborn rats: a sex‐specific balance between allopregnanolone and progesterone receptors Experimental physiology · 2017 · 17 citations
    18. Inhibitory respiratory responses to progesterone and allopregnanolone in newborn rats chronically treated with caffeine The Journal of Physiology · 2015 · 17 citations
    19. Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors 2018 · 16 citations
    20. Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice Brain Research · 2006 · 13 citations
    21. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation Psychoneuroendocrinology · 2019 · 12 citations
    22. The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain Neuroreport · 2011 · 11 citations
    23. Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats The Journal of Steroid Biochemistry and Molecular Biology · 2014 · 10 citations
    24. Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells International journal of molecular sciences · 2018 · 9 citations
    25. Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice Neuroscience Letters · 2013 · 8 citations
    26. Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model Scientific reports · 2019 · 6 citations
    27. Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats Journal of pharmacological sciences · 2018 · 4 citations
    28. Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models General Physiology and Biophysics · 2018 · 4 citations
    29. Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse Neurobiology of Stress · 2019 · 2 citations
    30. Effects of Restraint Stress and Allopregnanolone Inhibition on Amphetamine Locomotor Sensitivity Digital Scholarship - UNLV (University of Nevada Reno) · 2013 · 1 citations