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    Glossary Allopregnanolone

    neurosteroid derived from progesterone that modulates brain activity

    Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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    1. How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that Reddit · 31 May 2025
    2. How come dutasteride doesn't lower allopregnanolone, but finasteride does? Reddit · 8 Jan 2025
    3. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    4. Research and Question about Allopregnanolone, Multiple Sclerosis, TRT, and Finasteride Reddit · 7 Nov 2022
    5. Allopregnanolone deficiency by 5-ari inhibition (fin/dut users) Reddit · 11 Dec 2023
    6. Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight? Reddit · 22 May 2024
    7. So it turns out Post Finasteride Syndrome was never real? Reddit · 30 Jul 2024
    8. Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral. Reddit · 20 Jul 2024
    9. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    10. What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas Reddit · 25 Jun 2024
    11. Why isn't anybody on topical bicalutamide? Reddit · 16 Jun 2024
    12. We are manipulating our hormones, surely it's prudent to track bloodwork ? Reddit · 19 Apr 2024
    13. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    14. Progressive insomnia (treatment-resistant) due to Finasteride Reddit · 1 Jun 2022
    15. PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering Reddit · 30 Apr 2022
    16. I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story Reddit · 28 Sept 2021
    17. For what it's worth, I just want to state that I also think that adding Dutasteride to Finasteride has made my hair worse Reddit · 1 Jun 2021
    18. Insomnia and Finasteride Reddit · 29 Apr 2021
    19. A warning to those using or thinking about using Dutasteride – Follow-up Reddit · 13 Mar 2021
    20. Trying to understand finasteride side effects and post finasteride syndrome Reddit · 31 Oct 2020
    21. Why use Finasteride instead of Dutasteride? Reddit · 9 Feb 2024