Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

    July 2008 in “ Neuroscience ”
    Elena Martín-García, Sònia Darbra, Marc Pallarès
    Image of study
    TLDR Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.
    Neonatal administration of finasteride, a 5alpha-reductase inhibitor, led to anxiogenic-like behavior and decreased passive avoidance in adult rats after intrahippocampal neurosteroid administration. The study suggests that changes induced neonatally can have behavioral consequences in adulthood, in the reaction to emotional cues and also in the capability to learn experiences associated with high emotional stimuli, as punishment.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community risks with finasteride and dutasteride

      in Research/Science  141 upvotes 2 weeks ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  70 upvotes 4 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Related Research

    1 / 1 results