Finasteride Delays the Onset of Maternal Behavior in Primigravid Rats

July 2006 in “ Physiology & Behavior ”

Phyllis E. Mann

finasteride progesterone allopregnanolone Propecia

TLDR Finasteride slows down motherly behavior in first-time pregnant rats.

The study investigated the effect of finasteride, a drug used to treat hair loss, on maternal behavior in primigravid rats. The results showed that finasteride delayed the onset of maternal behavior and increased anxiety-like behaviors in rats. The study suggests that progesterone plays a role in inhibiting maternal behavior, but it is unknown which specific progesterone receptors are involved. The conversion of progesterone to allopregnanolone is unlikely to underlie progesterone's inhibitory actions on maternal behavior. The study was supported by NIH grants.

View this study on sciencedirect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 73 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 151 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Is it possible that dutasteride won’t make you depressedd if finasteride did?

in Chat 16 upvotes 8 months ago

The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.

Related Research

3 / 3 results