The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches

    January 2004 in “ Pharmacology & Therapeutics ”
    Deborah A. Finn, Matthew M. Ford, Kristine M. Wiren … John C. Crabbe
    Studysummary This review explores the potential role of pregnane neurosteroids in modulating alcohol withdrawal symptoms, suggesting a therapeutic target for treating alcohol dependence, but reports no new clinical results.
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    Research cited in this study 4

    1. Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride Journal of Neurochemistry · 2002
    2. Finasteride Blocks Progesterone Synthesis in MA-10 Leydig Tumor Cells Endocrinology · 1993
    3. Finasteride Blocks Progesterone Synthesis in MA-10 Leydig Tumor Cells Endocrinology · 1993
    4. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990