The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches

    January 2004 in “ Pharmacology & Therapeutics ”
    Deborah A. Finn, Matthew M. Ford, Kristine M. Wiren, Charles E. Roselli, John C. Crabbe
    TLDR Adjusting neurosteroid levels may help reduce alcohol withdrawal symptoms.
    The study investigated the impact of pregnane neurosteroids, especially allopregnanolone (ALLOP), on ethanol withdrawal, emphasizing their interaction with GABAA receptors. It was observed that chronic ethanol exposure and withdrawal altered neurosteroid levels and sensitivity, with seizure-prone animals exhibiting reduced ALLOP levels and tolerance to its anticonvulsant effects. Adjusting ALLOP levels using finasteride lessened withdrawal severity. Genetic research indicated interactions between GABAA receptor subunits and the enzyme 5α-reductase, suggesting that neurosteroid biosynthesis could be a therapeutic target for alcohol dependence. The study underscored the potential of neurosteroid treatment during ethanol withdrawal and proposed that genetic variations might affect withdrawal severity.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 273 results

      community Finasteride does deplete important nuero-active steroids

      in Research/Science  9 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community Do it yourself topical Fin and Min solution works

      in Progress Pictures  119 upvotes 3 months ago
      A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

      community Huge anxiety after taking finasteride

      in Treatment  25 upvotes 2 weeks ago
      The user experiences severe anxiety and physical symptoms after taking finasteride and is seeking alternative hair loss treatments since dutasteride is unavailable. They suspect an allergic reaction to finasteride and have stopped using it.

    Similar Research

    5 / 1000+ results