Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

    December 2015 in “ Journal of Neuroendocrinology ”
    Patrizia Porcu, Anna M. Barron, Cheryl A. Frye … Roberto Cosimo Melcangi
    Studysummary This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.
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    Research cited in this study 10

    1. New Steps Forward in the Neuroactive Steroid Field The Journal of Steroid Biochemistry and Molecular Biology · 2015
    2. Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies Psychopharmacology · 2014
    3. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    4. Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment Psychopharmacology · 2014
    5. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    6. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    7. Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation Journal of Neuroscience · 2011
    8. Changes in Expression and Function of Extrasynaptic GABA A Receptors in the Rat Hippocampus During Pregnancy and After Delivery Journal of Neuroscience · 2009
    9. Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective Journal of Neurobiology · 2006
    10. GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride Neuropsychopharmacology · 2005

    Related research 1

    1. Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats European Journal of Pharmacology · 2007