Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective

    June 2006 in “ Journal of Neurobiology ”
    Iratxe Ciriza, Paloma Carrero, Cheryl A. Frye, Luis Miguel García‐Segura
    Studysummary This study reports that progesterone metabolism to DHP and THP is necessary for its neuroprotective effect against kainic acid excitotoxicity in ovariectomized rats, unlike the synthetic progestin MPA.
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    Research cited in this study 2

    1. Inhibiting Biosynthesis and Metabolism of Progestins in the Ventral Tegmental Area Attenuates Lordosis in Rats During Behavioral Estrus Journal of Neuroendocrinology · 2005
    2. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999