Novel Anticonvulsive Effects of Progesterone in a Mouse Model of Hippocampal Electrical Kindling

November 2013 in “ Neuroscience ”

Melanie Jeffrey, Min Lang, Jonathan Gane, Elbert Chow, Chenggang Wu, Liang Zhang

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Research cited in this study

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research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

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Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

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Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.

research Allopregnanolone, the Active Metabolite of Progesterone, Protects Against Neuronal Damage in Picrotoxin-Induced Seizure Model in Mice

29 citations , October 2009 in “Pharmacology Biochemistry and Behavior”

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective

123 citations , June 2006 in “Journal of Neurobiology”

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

48 citations , February 1999 in “PubMed”

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.