Novel Anticonvulsive Effects of Progesterone in a Mouse Model of Hippocampal Electrical Kindling

    November 2013 in “ Neuroscience ”
    Melanie Jeffrey, Min Lang, Jonathan Gane … Liang Zhang
    Studysummary This study suggests that progesterone has both THP/GABAA-dependent and independent anticonvulsive effects in a hippocampal-kindled mouse model.
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    Research cited in this study 7

    1. Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis Epilepsy & Behavior · 2012
    2. Finasteride Expert Opinion on Drug Metabolism & Toxicology · 2010
    3. Allopregnanolone, the Active Metabolite of Progesterone, Protects Against Neuronal Damage in Picrotoxin-Induced Seizure Model in Mice Pharmacology Biochemistry and Behavior · 2009
    4. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    5. Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective Journal of Neurobiology · 2006
    6. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    7. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999