Novel Anticonvulsive Effects of Progesterone in a Mouse Model of Hippocampal Electrical Kindling

November 2013 in “ Neuroscience ”

Melanie Jeffrey, Min Lang, Jonathan Gane, Elbert Chow, Chenggang Wu, Liang Zhang

progesterone THP finasteride GABAA receptor Propecia

TLDR Progesterone can reduce seizures without relying on the GABAA receptor pathway.

The study explored the anticonvulsive effects of progesterone in a mouse model of hippocampal kindling, revealing that progesterone suppressed seizures even when its conversion to the active metabolite THP was inhibited by finasteride. This indicated that progesterone might possess anticonvulsive properties independent of the GABAA receptor pathway. The research, conducted on adult male mice, demonstrated that progesterone could reduce cortical afterdischarges and motor seizures, supporting the hypothesis of THP/GABAA-independent anticonvulsive actions.

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Research cited in this study

7 / 7 results

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

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research Allopregnanolone, the Active Metabolite of Progesterone, Protects Against Neuronal Damage in Picrotoxin-Induced Seizure Model in Mice

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research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

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research Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective

123 citations , June 2006 in “Journal of Neurobiology”

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research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

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research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

48 citations , February 1999 in “PubMed”

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

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Novel Anticonvulsive Effects of Progesterone in a Mouse Model of Hippocampal Electrical Kindling

Research cited in this study

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

research Finasteride

research Allopregnanolone, the Active Metabolite of Progesterone, Protects Against Neuronal Damage in Picrotoxin-Induced Seizure Model in Mice

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

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