TLDR Progesterone can reduce seizures without relying on the GABAA receptor pathway.
The study explored the anticonvulsive effects of progesterone in a mouse model of hippocampal kindling, revealing that progesterone suppressed seizures even when its conversion to the active metabolite THP was inhibited by finasteride. This indicated that progesterone might possess anticonvulsive properties independent of the GABAA receptor pathway. The research, conducted on adult male mice, demonstrated that progesterone could reduce cortical afterdischarges and motor seizures, supporting the hypothesis of THP/GABAA-independent anticonvulsive actions.
26 citations
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July 2012 in “Epilepsy & Behavior” Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.
10 citations
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June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
29 citations
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October 2009 in “Pharmacology Biochemistry and Behavior” 
61 citations
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January 2008 in “Biological & Pharmaceutical Bulletin” Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
123 citations
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June 2006 in “Journal of Neurobiology” Progesterone protects brain cells, but Provera does not.
137 citations
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March 2006 in “Cns Drug Reviews” Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
48 citations
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February 1999 in “PubMed” Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.
