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Glossary GABAA Receptors

ion channels in the brain that reduce neuronal excitability

GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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Research

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research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.

research Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

40 citations , December 2019 in “Neurobiology of Stress”

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

research Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mechanism of action

17 citations , October 2012 in “European Journal of Pharmacology”

This study found that inhaling toluene reduces core temperature in mice, with GABA receptors and neurosteroids involved at 4000 ppm, but different mechanisms contributing at 6000 ppm.

research Activation of extrasynaptic δ-GABAA receptors globally or within the posterior-VTA has estrous-dependent effects on consumption of alcohol and estrous-independent effects on locomotion

14 citations , September 2017 in “Hormones and behavior”

This study found that the estrous cycle influences the effect of the δ-GABAAR agonist THIP in reducing binge drinking behavior in female mice, with receptor expression elevated during diestrus.

research PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields

14 citations , March 2017 in “Brain research”

This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.

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community After praising finasteride on this sub for a while I realised it gave me Brain Fog. I think its related to inhibiting GABA and interferring with mirtazapine (an antidepressant).

9 upvotes 6 years ago

Finasteride caused brain fog and reduced the effectiveness of mirtazapine for the user, leading them to stop finasteride and notice improvements in motivation and focus. The user suggests that finasteride might be incompatible with mirtazapine for some people and recommends mirtazapine for those experiencing mental fog from finasteride.

community Finasteride, Neurosteroids, and Neuroplasticity - have you noticed cognitive shifts or have you continued growing?

in Basic Questions 201 upvotes 3 months ago

The conversation discusses concerns about potential cognitive and emotional effects of finasteride, with the original poster planning to monitor their cognitive performance while using the treatment. A user responds that most people do not experience cognitive shifts, though some report subtle changes.

community Do it yourself topical Fin and Min solution works

in Progress Pictures 119 upvotes 1 year ago

A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 1 year ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

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