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    Glossary GABAA Receptors

    ion channels in the brain that reduce neuronal excitability

    GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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    Research 30 of 658

    1. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes Pain · 2009 · 44 citations
    2. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    3. Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mechanism of action European Journal of Pharmacology · 2012 · 17 citations
    4. Activation of extrasynaptic δ-GABAA receptors globally or within the posterior-VTA has estrous-dependent effects on consumption of alcohol and estrous-independent effects on locomotion Hormones and behavior · 2017 · 14 citations
    5. PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields Brain research · 2017 · 14 citations
    6. Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids Molecular and Cellular Neuroscience · 2016 · 11 citations
    7. Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors Neuroscience letters · 2019 · 5 citations
    8. Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids 2020
    9. Modificazioni nella funzionalità , nell'espressione dei recettori GABAA extrasinaptici e nella plasticità  sinaptica nell'ippocampo di ratto durante la gravidanza e dopo il parto. 2009
    10. Social isolation alters GABAA receptors plasticity and function: effect of voluntary consumption of ethanol Annals of General Psychiatry · 2008
    11. Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice The FASEB Journal · 2008
    12. Ovarian Cycle‐Related Neurosteroid Regulation of GABA‐A Receptor Subunit Plasticity in the Hippocampus Subfields The FASEB Journal · 2011 · 1 citations
    13. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain Journal of neuroscience research · 2017 · 12 citations
    14. S.04.04 Social isolation alters GABAA receptors plasticity and function: effect of ethanol European Neuropsychopharmacology · 2007
    15. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011 · 34 citations
    16. P.1.g.019 RY-023, an inverse agonist at alpha5 GABAA receptors: the influence on spatial memory and spontaneous locomotor activity European Neuropsychopharmacology · 2008
    17. Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice Brain Research · 2005 · 35 citations
    18. Changes in expression of the δ subunit of the GABA<sub>A</sub>receptor and in receptor function induced by progesterone exposure and withdrawal Journal of Neurochemistry · 2006 · 25 citations
    19. Respiratory regulation by steroids in newborn rats: a sex‐specific balance between allopregnanolone and progesterone receptors Experimental physiology · 2017 · 17 citations
    20. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors Journal of Ethnopharmacology · 2009 · 17 citations
    21. The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses Epilepsia · 2005 · 13 citations
    22. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation Psychoneuroendocrinology · 2019 · 12 citations
    23. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015 · 33 citations
    24. Joint Public Review: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2 2024
    25. Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors 2018 · 16 citations
    26. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    27. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    28. The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches Pharmacology & Therapeutics · 2004 · 83 citations
    29. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations
    30. Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice Pharmacology Biochemistry and Behavior · 2008 · 66 citations