Cinnamic Acid Promotes Elongation of Hair Peg-Like Sprouting in Hair Follicle Organoids via Oxytocin Receptor Activation

The research investigated the impact of cinnamic acid, a component of Cinnamomum cassia, on hair growth. It was found that cinnamic acid increased the expression of oxytocin receptor (OXTR) and hair growth-related genes in dermal papilla (DP) cells. In an in vitro hair follicle growth model, cinnamic acid promoted hair growth, with a dose-dependent increase in OXTR and hair growth-related genes expression at concentrations below 500 µg/mL. The study also demonstrated that cinnamic acid promotes the elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation. These findings suggest the potential use of cinnamic acid in treating hair loss, but further research is required to confirm these results and assess the efficacy of cinnamic acid in patients with multiple alopecias.