Cinnamic Acid Promotes Elongation of Hair Peg-Like Sprouting in Hair Follicle Organoids via Oxytocin Receptor Activation

February 2024 in “ Scientific Reports ”

Tatsuto Kageyama, Jieun Seo, Lu Yan, Junji Fukuda

cinnamic acid Cinnamomum cassia oxytocin receptor OXTR dermal papilla cells hair follicle organoids hair peg-like sprouting hair growth-related genes alopecia cinnamon DP cells hair follicle models hair growth genes hair loss

Studysummary In this study, cinnamic acid was found to enhance hair growth in human dermal papilla cells and hair follicle organoids by activating oxytocin signaling, suggesting its potential for developing hair growth-promoting products. Our plain-language summary of this paper — not a Tressless recommendation.

The research investigated the impact of cinnamic acid, a component of Cinnamomum cassia, on hair growth. It was found that cinnamic acid increased the expression of oxytocin receptor (OXTR) and hair growth-related genes in dermal papilla (DP) cells. In an in vitro hair follicle growth model, cinnamic acid promoted hair growth, with a dose-dependent increase in OXTR and hair growth-related genes expression at concentrations below 500 µg/mL. The study also demonstrated that cinnamic acid promotes the elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation. These findings suggest the potential use of cinnamic acid in treating hair loss, but further research is required to confirm these results and assess the efficacy of cinnamic acid in patients with multiple alopecias.

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research Effects of Oxytocin on the Hair Growth Ability of Dermal Papilla Cells

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This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.

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research An Overview of the Genetic Aspects of Hair Loss and Its Connection with Nutrition

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research Impacts of Manipulating Cell Sorting on In Vitro Hair Follicle Regeneration

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This study found that Y27632 treatment facilitated the formation of core-shell-shaped hair follicle organoids, resulting in nearly 100% efficient hair shaft sprouting in vitro.

research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

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This review discusses treatment options for androgenetic alopecia, highlighting the need for personalized, evidence-based approaches but reports no new clinical results.

research Effect of Cinnamomum Osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth

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This study found that the water extract of Cinnamomum osmophloeum Kanehira leaves enhanced hair growth in vitro and in a mouse model, suggesting potential use for treating hair loss.