Anti-Inflammatory Loading of Cinnamaldehyde on Artificial Bone Scaffolds Against Bone Regeneration

    December 2023 in “ Majalah Kedokteran Gigi Indonesia ”
    Anne Handrini Dewi, Andi Triawan, John Jansen
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    TLDR Cinnamaldehyde helps bone healing initially but may slow healing later unless combined with DHT treatment.
    This study investigated the effects of loading cinnamaldehyde onto gypsum-hydrogel calcium carbonate scaffolds for bone regeneration in 20 Sprague-Dawley rats. The results indicated that cinnamaldehyde effectively reduced inflammation and promoted bone healing in the initial weeks (1 and 4 weeks) post-implantation. However, by 8 weeks, cinnamaldehyde appeared to inhibit defect closure. The combination of cinnamaldehyde with dehydrothermal (DHT) treatment showed improved outcomes compared to cinnamaldehyde alone.
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