Effect of Injectable Calcium Alginate-Amelogenin Hydrogel on Macrophage Polarization and Promotion of Jaw Bone Osteogenesis
July 2023
Studysummary This study found that an injectable calcium alginate-amelogenin hydrogel is biocompatible, degradable, anti-inflammatory, and promotes osteogenesis, which may enhance the bone healing process in jaw and facial bone defect areas by mediating the bone immune microenvironment.
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The study explores the effects of an injectable calcium alginate-amelogenin hydrogel (CA+AM) on macrophage polarization and jaw bone osteogenesis. The hydrogel demonstrated good biosafety, structural stability, and mechanical strength, effectively promoting macrophage polarization towards the M2 phenotype, which is linked to anti-inflammatory responses and bone healing. In vitro, CA+AM enhanced the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, while in vivo, it significantly reduced bleeding and alveolar ridge resorption in a rat model, indicating its potential for bone regeneration and tissue repair. The study involved 30 healthy male SD rats and showed that CA+AM hydrogel could be a promising material for bone regeneration and wound healing in dental applications.
