FGF-9 Accelerates Epithelial Invagination for Ectodermal Organogenesis in Real-Time Bioengineered Organ Manipulation

November 2012 in “ Cell Communication and Signaling ”

Yun-Yuan Tai, Rung‐Shu Chen, Yi Lin, Thai‐Yen Ling, Min‐Huey Chen

Fibroblast growth factor-9 FGF-9 epithelial invagination ectodermal organogenesis bioengineered organs Ameloblastin Amelogenin odontogenesis FGF-BMP balancing system

TLDR FGF-9 speeds up the early development of certain organs, showing potential for organ regeneration.

The study demonstrated that Fibroblast Growth Factor-9 (FGF-9) accelerated epithelial invagination in bioengineered ectodermal organs, particularly in reaggregated mesenchymal cell layers, within 3 days. Using a bioengineered organ model combined with Electric Cell-Substrate Impedance Sensing (ECIS), researchers observed that FGF-9 stimulated the expression of key odontogenic genes such as Ameloblastin and Amelogenin, promoting early tooth germ development. The study highlighted the potential of FGF-9 in tissue engineering and organ regeneration, proposing an 'FGF-BMP balancing system' that influences ectodermal organ morphogenesis. This research provided new insights into manipulating the speed of ectodermal organ regeneration, with implications for developmental biology and regenerative medicine.

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