TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

February 2017 in “ Cold Spring Harbor Perspectives in Biology ”

Kaoru Kahata, Mahsa Shahidi Dadras, Aristidis Moustakas

Studysummary The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

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research Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis

31 citations , April 2016 in “Nature communications”

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

research Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells

142 citations , February 2016 in “Science”

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research Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

115 citations , February 2016 in “Nature Communications”

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

research BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

84 citations , October 2014 in “PLoS Genetics”

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

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research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

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research Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate

394 citations , October 2013 in “Nature”

Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

31 citations , September 2013 in “Stem Cells”

This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.

research Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes

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research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

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research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

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research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

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research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

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This study found that activating β-catenin signaling in embryonic epidermis promoted hair follicle characteristics at the expense of normal epidermal differentiation, leading to early pigmentation and innervation.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

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research Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

92 citations , November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that transgenic mice overexpressing the BMP antagonist noggin showed increased hair follicle size and altered hair type, linked to changes in cell proliferation and gene expression.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

This study found that active BMP signaling prevents epithelial stem cell activation and expansion in hair follicles, while its inhibition leads to HF stem/progenitor cell overproduction and matricomas.

research Stem Cells and Their Niches

1549 citations , March 2006 in “Science”

This review discusses the stem cell niche concept in mammalian systems and reports no new clinical results, highlighting recent progress and identifying important unanswered questions.

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1279 citations , November 2005 in “Nature Medicine”

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

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research Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models

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This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

250 citations , November 2003 in “The Journal of Cell Biology”

This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations , January 2003 in “The FASEB Journal”

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research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

158 citations , December 2002 in “Development”

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research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues

111 citations , June 2002 in “The EMBO Journal”

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211 citations , October 2001 in “The FASEB Journal”

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Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

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745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.