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Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation

research 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation

September 2019 in “Journal of Investigative Dermatology”

This study found that BMPs can counteract the inhibitory effects of androgens on hair follicle stem cell differentiation, highlighting their critical role in the pathway dysregulation seen in androgenetic alopecia.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation

2 citations , February 2022 in “Human Gene Therapy”

This study found that upregulated miR-149 restricted hair follicle stem cell differentiation and hair growth by inhibiting the MAPK1/ERK2 pathway, which affects FGF2 and c-MYC expression.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

research Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

4 citations , July 2021 in “Frontiers in Cell and Developmental Biology”

This study demonstrates that the transcription factor DLX5 can promote hair follicle stem cell differentiation through regulating the c-MYC/miR-29c-3p/NSD1 axis.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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