Dermal Fibroblasts in Cutaneous Development and Healing

    December 2017 in “ Wiley Interdisciplinary Reviews-Developmental Biology ”
    Venkata Thulabandu, Demeng Chen, Radhika P. Atit
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    TLDR Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
    The 2017 document "Dermal fibroblast in cutaneous development and healing" discussed the crucial role of dermal fibroblasts in skin development, hair follicle initiation, and wound healing. The study emphasized the heterogeneity and plasticity of these cells, which differentiate into various cell types, each with specific functions. It also highlighted the role of papillary and reticular dermal lineages, dermal white adipose tissue (DWAT), and WNT signaling in skin development. The document underscored the need for further research in several areas, including understanding the differentiation program of dermal derivatives, the role of the HOX code in skin patterning, and the regulatory mechanisms involved in scar-free wound healing. The study did not provide specific numbers of participants.
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