Dermal Fibroblasts in Cutaneous Development and Healing

December 2017 in “ Wiley Interdisciplinary Reviews-Developmental Biology ”

Venkata Thulabandu, Demeng Chen, Radhika P. Atit

dermal fibroblasts hair follicle initiation wound healing papillary dermal lineages reticular dermal lineages dermal white adipose tissue DWAT WNT signaling HOX code scar-free wound healing skin development hair growth fat tissue WNT pathway scarless healing

Studysummary This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The 2017 document "Dermal fibroblast in cutaneous development and healing" discussed the crucial role of dermal fibroblasts in skin development, hair follicle initiation, and wound healing. The study emphasized the heterogeneity and plasticity of these cells, which differentiate into various cell types, each with specific functions. It also highlighted the role of papillary and reticular dermal lineages, dermal white adipose tissue (DWAT), and WNT signaling in skin development. The document underscored the need for further research in several areas, including understanding the differentiation program of dermal derivatives, the role of the HOX code in skin patterning, and the regulatory mechanisms involved in scar-free wound healing. The study did not provide specific numbers of participants.

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