TLDR Skin sheath cells help in hair growth and renewal after birth.
The document from 7 years ago discussed the role of fibroblasts, specifically dermal papilla (DP) and dermal sheath (DS) cells, and keratinocytes in the production and maintenance of hair follicles. It highlighted that while keratinocytes are the primary constituents of hair follicles that generate the hair structure, the contribution of dermal fibroblasts to hair follicle neogenesis and regeneration is less well defined. The paper noted that DP cells of growing follicles possess hair-inducing ability and interact with keratinocytes to achieve regenerative hair growth. However, attempts to elicit human follicle neogenesis with cultured human DP cells have not been very successful, partly because they lose inductivity during passaging. The document suggested that more research was needed to better understand the role of the mesenchyme in intact follicles, particularly the DS, which had received little attention.
184 citations,
November 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
208 citations,
December 2003 in “Journal of Investigative Dermatology” Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
KY19382 helps to regrow hair and create new hair follicles.
September 2016 in “Journal of Dermatological Science” Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
26 citations,
July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
15 citations,
July 2016 in “Biochemical Journal” Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.
24 citations,
April 2012 in “Developmental Biology” Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
207 citations,
March 2012 in “Development” Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
61 citations,
October 1996 in “Development” Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.
