CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth

July 2016 in “ Biochemical Journal ”

Linli Zhou, Kun Yang, April C. Carpenter, Richard A. Lang, Thomas Andl, Yuhang Zhang

CD133-positive dermal papilla Wnt ligands postnatal hair growth Wntless gene hair follicle regression anagen DP marker matrix keratinocytes melanocytes mesenchyme-epithelial signaling hair growth regeneration CD133+ DP cells Wnt proteins Wls gene hair follicle shrinkage hair growth markers skin cells pigment cells cell signaling hair regrowth

Studysummary This study found that Wnt ligands from CD133-positive dermal papilla cells are essential for maintaining hair growth by supporting cell signaling between different hair follicle structures.

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