The Hair Cycle
February 2006
in “
Journal of Cell Science
”
hair cycle anagen catagen telogen hair follicles hair shafts stem cells cell proliferation differentiation apoptosis hair follicle morphogenesis dermal papilla FGF5 EGF TGFB Wnts Shh growth phase regression phase rest phase hair roots hair strands cell growth cell death skin development skin papilla fibroblast growth factor 5 epidermal growth factor transforming growth factor beta Wnt signaling Sonic hedgehog
TLDR The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
The document discussed the hair cycle, a critical process for hair renewal in mammals, comprising three phases: anagen (growth), catagen (regression), and telogen (rest). It explained how hair follicles produce hair shafts during anagen and prepare stem cells for the next growth phase during catagen and telogen. The hair cycle serves as a model for studying various biological processes in regenerative adult epithelial tissue, including stem cell behavior, cell proliferation, differentiation, and apoptosis. The paper also covered hair follicle morphogenesis during embryonic development and the role of the dermal papilla. It identified key molecular regulators of the hair cycle phase transitions, such as FGF5, EGF, and TGFB, and the activation of stem cells by signals like Wnts and Shh at the transition from telogen to anagen, underscoring the complexity of the hair cycle involving multiple cell types and molecular pathways.
