The hair cycle
February 2006
in “Journal of Cell Science”
TLDR The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
The document discussed the hair cycle, a critical process for hair renewal in mammals, comprising three phases: anagen (growth), catagen (regression), and telogen (rest). It explained how hair follicles produce hair shafts during anagen and prepare stem cells for the next growth phase during catagen and telogen. The hair cycle serves as a model for studying various biological processes in regenerative adult epithelial tissue, including stem cell behavior, cell proliferation, differentiation, and apoptosis. The paper also covered hair follicle morphogenesis during embryonic development and the role of the dermal papilla. It identified key molecular regulators of the hair cycle phase transitions, such as FGF5, EGF, and TGFB, and the activation of stem cells by signals like Wnts and Shh at the transition from telogen to anagen, underscoring the complexity of the hair cycle involving multiple cell types and molecular pathways.
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Cited in this study
research Hair Follicle Stem Cells
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.