The Hair Cycle

    February 2006 in “ Journal of Cell Science ”
    Laura Alonso, Elaine Fuchs
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    TLDR The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
    The document discussed the hair cycle, a critical process for hair renewal in mammals, comprising three phases: anagen (growth), catagen (regression), and telogen (rest). It explained how hair follicles produce hair shafts during anagen and prepare stem cells for the next growth phase during catagen and telogen. The hair cycle serves as a model for studying various biological processes in regenerative adult epithelial tissue, including stem cell behavior, cell proliferation, differentiation, and apoptosis. The paper also covered hair follicle morphogenesis during embryonic development and the role of the dermal papilla. It identified key molecular regulators of the hair cycle phase transitions, such as FGF5, EGF, and TGFB, and the activation of stem cells by signals like Wnts and Shh at the transition from telogen to anagen, underscoring the complexity of the hair cycle involving multiple cell types and molecular pathways.
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