Histopathology of Aging of the Hair Follicle

    April 2019 in “ Journal of Cutaneous Pathology ”
    Ángel Fernández-Flores, Marcela Saeb‐Lima, David S. Cassarino
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    TLDR Hair becomes gray and thin as we age, and while most hair loss in older people is due to genetics, there's a chance for gray hair to regain color under certain conditions.
    The 2019 document discussed the aging process of hair follicles, focusing on hair graying and thinning. It explained that hair becomes dry, thin, dull, and brittle with age due to decreased melanin production, leading to graying. The concept of senile alopecia, a type of hair loss due to aging, was discussed, but it was noted that most cases of alopecia in older individuals are androgenetic. The paper also discussed the thinning of hair follicles with age and stated that about 50% of the population will have 50% gray hair by the age of 50. The document also detailed the hair cycle, noting that the telogen phase lengthens with age, leading to hair graying or whitening after 40 to 45 years of age. The paper concluded by discussing the potential for hair repigmentation, as inactive melanocytes remain in the outer root sheath of white hair follicles, suggesting that hair repigmentation is possible under certain conditions.
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