Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

    December 2018 in “ Experimental Dermatology
    Weiming Qiu, Cheng‐Ming Chuong, Mingxing Lei
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    TLDR Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.
    The document from January 15, 2019, reviews the role of melanocyte stem cells (McSCs) in skin and hair follicle pigmentation, their regulation, and potential therapeutic applications for pigmentation disorders. It highlights the importance of the transcription factor MITF in melanogenesis and the regulation of McSCs by various signaling pathways, including Wnt/ß-catenin and TGF-ß. The review also discusses the interaction between McSCs and other skin cells, the contribution of McSCs to epidermal melanocyte repopulation after injury, and the role of McSCs in hair graying. It suggests that a deeper understanding of McSC regulation could lead to treatments for conditions like canities and vitiligo, but acknowledges that there are still unanswered questions in the field.
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