TLDR EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
The study by Takeo et al. from 2016 explored the significance of Endothelin Receptor B (EdnrB) signaling in the regeneration of melanocyte stem cells (McSCs) and its synergistic relationship with the Wnt signaling pathway. The research demonstrated that overexpression of Endothelin 1 (Edn1) in epithelial cells enhances the proliferation, differentiation, and migration of McSCs during the hair growth phase without causing stem cell depletion or premature graying. The study also showed that Edn1 overexpression could compensate for the loss of melanocortin 1 receptor (Mc1R) function, which is important for pigmentation and melanocyte migration. These findings suggest that Edn/EdnrB signaling could be a potential therapeutic target for promoting melanocyte regeneration and treating pigmentation disorders. The study did not specify the number of mice used in the experiments.
170 citations,
January 2013 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
260 citations,
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240 citations,
May 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
829 citations,
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450 citations,
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240 citations,
May 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
17 citations,
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10 citations,
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75 citations,
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