TLDR EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
The study by Takeo et al. from 2016 explored the significance of Endothelin Receptor B (EdnrB) signaling in the regeneration of melanocyte stem cells (McSCs) and its synergistic relationship with the Wnt signaling pathway. The research demonstrated that overexpression of Endothelin 1 (Edn1) in epithelial cells enhances the proliferation, differentiation, and migration of McSCs during the hair growth phase without causing stem cell depletion or premature graying. The study also showed that Edn1 overexpression could compensate for the loss of melanocortin 1 receptor (Mc1R) function, which is important for pigmentation and melanocyte migration. These findings suggest that Edn/EdnrB signaling could be a potential therapeutic target for promoting melanocyte regeneration and treating pigmentation disorders. The study did not specify the number of mice used in the experiments.
170 citations,
July 2012 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
260 citations,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
240 citations,
April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
450 citations,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
April 2023 in “Journal of Investigative Dermatology” Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.
240 citations,
April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
17 citations,
December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
10 citations,
November 2010 in “Pigment Cell & Melanoma Research” Only skin melanocytes, not other types, can color hair in mice.
75 citations,
January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
