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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research The Color of Human Hair

1 citations , January 2012 in “Human health handbooks”

Hair color is determined by melanin types and gene activity.

research Spectrum of Phenotypes Associated with Human MC1R Variations

June 2025 in “Albus Scientia”

MC1R gene variations affect skin, hair color, UV sensitivity, and melanoma risk.

research Piecing Together the Pigment-Type Switching Puzzle

10 citations , November 2009 in “Pigment cell & melanoma research”

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

research Regrowth of Black Hair in Two Red-Haired Alopecia Areata Patients

5 citations , February 2012 in “Australasian Journal of Dermatology”

Two red-haired men with alopecia areata regrew black hair instead of red.

research Melanocytes and Vitiligo and Hair Graying

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

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