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    Glossary Agouti Signaling Protein

    protein influencing hair color by inhibiting melanocortin 1 receptor

    Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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    1. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    2. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    3. Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds Genetics selection evolution · 2019 · 30 citations
    4. Efficacy of an agonist of<i>α</i>-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation International Journal of Cosmetic Science · 2018 · 12 citations
    5. Piecing together the pigment-type switching puzzle Pigment cell & melanoma research · 2009 · 10 citations
    6. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    7. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    8. Siberian cats help in solving part of the mystery surrounding golden cats Animal Genetics · 2021 · 7 citations
    9. Agouti and Agouti-related Protein: Analogies and Contrasts Journal of Biological Chemistry · 2000 · 135 citations
    10. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
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