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    Glossary Smoothened Receptor

    protein involved in Hedgehog signaling pathway for cell growth

    The Smoothened Receptor (SMO) is a protein that plays a crucial role in the Hedgehog signaling pathway, which is important for regulating cell growth and development. When activated, SMO helps transmit signals from the cell surface to the inside of the cell, influencing processes like tissue patterning and stem cell maintenance. Malfunctions in this pathway can lead to developmental disorders and cancers.

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    Research 10 of 327

    1. Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects Journal of dermatological treatment · 2019 · 8 citations
    2. Effects of vinblastine and its metabolites on nausea and alopecia associated receptors 2018
    3. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations
    4. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    5. Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma Clinical Cancer Research · 2015 · 16 citations
    6. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    7. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    8. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020 · 55 citations
    9. Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism Journal of Investigative Dermatology · 2008 · 51 citations
    10. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
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