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    Glossary Smoothened Receptor

    protein involved in Hedgehog signaling pathway for cell growth

    The Smoothened Receptor (SMO) is a protein that plays a crucial role in the Hedgehog signaling pathway, which is important for regulating cell growth and development. When activated, SMO helps transmit signals from the cell surface to the inside of the cell, influencing processes like tissue patterning and stem cell maintenance. Malfunctions in this pathway can lead to developmental disorders and cancers.

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    Research 30 of 325

    1. Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects Journal of dermatological treatment · 2019 · 8 citations
    2. Effects of vinblastine and its metabolites on nausea and alopecia associated receptors 2018
    3. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations
    4. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    5. Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma Clinical Cancer Research · 2015 · 16 citations
    6. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    7. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    8. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020 · 55 citations
    9. Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism Journal of Investigative Dermatology · 2008 · 51 citations
    10. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
    11. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    12. GPCRs as key regulators in wound healing Frontiers in Cell and Developmental Biology · 2026
    13. Adverse Hair Reactions to New Targeted Therapies for Cancer Actas Dermo-Sifiliográficas · 2019 · 1 citations
    14. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 2 citations
    15. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop Genes & Development · 2012 · 138 citations
    16. Voice changes in reproductive disorders, thyroid disorders and diabetes: a review Endocrine connections · 2022
    17. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    18. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    19. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    20. sm“FISH”ing for Hedgehog 2016
    21. Ptch2 is a Potential Regulator of Mesenchymal Stem Cells Frontiers in Physiology · 2022 · 3 citations
    22. Decision letter: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    23. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis Genes & Development · 2008 · 102 citations
    24. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations
    25. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling npj Regenerative Medicine · 2022 · 3 citations
    26. Shh Gene Regulates the Proliferation and Apoptosis of Dermal Papilla Cells to Affect Its Differential Expression in Secondary Hair Follicle Growth Cycle of Cashmere Goats Animals · 2024 · 7 citations
    27. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    28. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    29. Hair loss and Hedgehog inhibitors: a class effect? British Journal of Dermatology · 2014 · 9 citations
    30. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations