Effects of Bioactive Composition in Oryza Sativa L. Cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

January 2023 in “ Agronomy ”

Chiranan Khantham, Warintorn Ruksiriwanich, Korawan Sringarm, Chanakan Prom‐u‐thai, Sansanee Jamjod, Chaiwat Arjin, Anurak Muangsanguan, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Francisco J. Barba, Sarana Rose Sommano, Romchat Chutoprapat, Korawinwich Boonpisuttinant

Studysummary This research reported that KDML105 bran extract demonstrated antioxidant activities, reduced nitric oxide production, and influenced gene expression related to the hair cycle in cultured dermal papilla cells, suggesting potential as an anti-hair loss agent by supporting the anagen phase and angiogenesis. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of KDML105 bran extract, derived from Oryza sativa L., on gene expression related to hair growth in human hair follicle dermal papilla cells (HFDPCs). The extract contained several antioxidant compounds, including α- and γ-tocopherol, phytic acid, γ-oryzanol, chlorogenic acid, o-coumaric acid, palmitic acid, oleic acid, and linoleic acid. The extract demonstrated anti-inflammatory properties by significantly reducing nitrite levels in lipopolysaccharide-induced macrophages. It also influenced gene expression in HFDPCs, downregulating SRD5A2 and TGFB1 genes, and upregulating CTNNB1 and VEGF genes. These changes suggest the extract may aid in the induction and maintenance of the anagen phase and angiogenesis in hair follicles, potentially making it a source of anti-hair loss substances. However, the study did not mention the number of participants involved in the research.

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