Study on the Chemical Constituents of Nut Oil from Prunus Mira Koehne and the Mechanism of Promoting Hair Growth

April 2020 in “ Journal of ethnopharmacology ”

You Zhou, Guangmin Tang, Xiaoli Li, Weijun Sun, Yuan Liang, Deqiang Gan, Guangli Liu, Wen-Jie Song, Zhang Wang

Prunus mira Koehne nut oil α-tocopherol β-sitosterol Vitamin E Oleic acid linoleic acid hair follicle dermal thickness β-catenin GSK3β Wnt10b Wnt/β-catenin signaling pathway anagen phase Prunus mira skin thickness Wnt signaling pathway growth phase

TLDR Prunus mira nut oil helps hair grow by affecting the Wnt/β-catenin signaling pathway.

The study analyzed the chemical constituents of nut oil from Prunus mira and its mechanism in promoting hair growth. It identified key components such as vitamin E, β-sitosterol, α-tocopherol, oleic acid, and linoleic acid. Using a depilated mouse model, the study found that P. mira nut oil, in doses ranging from 15.06 to 60.26 mg/cm²/day, effectively promoted hair growth. The research suggested that the nut oil's mechanism involved the Wnt/β-catenin signaling pathway, which is crucial for hair follicle regeneration. This provided a potential alternative to existing hair growth treatments with fewer side effects.

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