Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

    November 2010 in “ Journal of Dermatological Science
    Shigeki Inui, Satoshi Itami
    Image of study
    TLDR Male pattern baldness involves hormones and cell signals affecting hair growth.
    This 12-year-old scientific paper explores the molecular basis of androgenetic alopecia (AGA), also known as male pattern baldness. The paper discusses the role of dihydrotestosterone (DHT) and its interaction with the androgen receptor (AR) in the pathogenesis of AGA. The paper also explores the role of paracrine mediators from dermal papilla cells, such as TGF-B and DKK-1, in the suppression of hair growth and early catagen induction in AGA. The paper concludes that the mechanism of AGA is tightly regulated at each step in the androgen signaling pathway and that more pathogenic mediators will likely be identified in the future, providing new therapeutic targets.
    Discuss this study in the Community →

    Research cited in this study

    25 / 25 results

    Related Community Posts Join

    6 / 1000+ results

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 4 weeks ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 6 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

      community Why is dht bad for scalp hair but good for hair on the rest of body?

      in Satire  109 upvotes 1 year ago
      The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    7 / 7 results