Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

    November 2010 in “ Journal of Dermatological Science ”
    Shigeki Inui, Satoshi Itami
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    TLDR Male pattern baldness involves hormones and cell signals affecting hair growth.
    This 12-year-old scientific paper explores the molecular basis of androgenetic alopecia (AGA), also known as male pattern baldness. The paper discusses the role of dihydrotestosterone (DHT) and its interaction with the androgen receptor (AR) in the pathogenesis of AGA. The paper also explores the role of paracrine mediators from dermal papilla cells, such as TGF-B and DKK-1, in the suppression of hair growth and early catagen induction in AGA. The paper concludes that the mechanism of AGA is tightly regulated at each step in the androgen signaling pathway and that more pathogenic mediators will likely be identified in the future, providing new therapeutic targets.
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      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  111 upvotes 1 month ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 1 year ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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