Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia

This study analyzed the genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. The results suggest that these polymorphisms may not be directly associated with the development of baldness or generation of different clinical phenotypes. However, there were racial differences in the distribution of polymorphisms for these two enzyme genes. The study also suggested that SRD5A1 and 2 gene polymorphisms might be associated with the therapeutic response to enzyme inhibitors such as finasteride. The SRD5A2 gene was found to be significantly associated with androgenetic alopecia in Korean men.