Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia

April 2003 in “ Journal of Dermatological Science ”

Seog-Jun Ha, Jung Hyun Kim, Jaewook Myung, Hyun-Jeong Lee, Jin-Soo Kim

steroid 5α-reductase type 1 steroid 5α-reductase type 2 androgenetic alopecia SRD5A1 SRD5A2 enzyme inhibitors finasteride Propecia

Studysummary This study found no significant associations between the polymorphisms of SRD5A1 and SRD5A2 genes and androgenetic alopecia, clinical types of baldness, or response to finasteride in Koreans. Our plain-language summary of this paper — not a Tressless recommendation.

This study analyzed the genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. The results suggest that these polymorphisms may not be directly associated with the development of baldness or generation of different clinical phenotypes. However, there were racial differences in the distribution of polymorphisms for these two enzyme genes. The study also suggested that SRD5A1 and 2 gene polymorphisms might be associated with the therapeutic response to enzyme inhibitors such as finasteride. The SRD5A2 gene was found to be significantly associated with androgenetic alopecia in Korean men.

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Research cited in this study

6 / 6 results

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.

research Can Male-Pattern Baldness Be Prevented? Promising Results from a Study on Treating Male-Pattern Baldness with Oral Finasteride

3 citations , July 1997 in “The Lancet”

Keith Kaufman reported promising results on treating male-pattern baldness with oral finasteride at the World Congress of Dermatology.

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

This article presents a classification system for stages of female-pattern androgenetic alopecia to aid early diagnosis and mentions existing systems for rare male-pattern cases, but reports no new clinical results.