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GlossarySteroid 5 Alpha-Reductase 1 (SRD5A1)

converts testosterone into a more potent androgen, dihydrotestosterone

Steroid 5 Alpha-Reductase 1 (SRD5A1) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

November 2023 in “Scientific reports”

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

research Differential Expression of Steroid 5α-Reductase Isozymes and Association with Disease Severity and Angiogenic Genes Predict Their Biological Role in Prostate Cancer

30 citations , June 2010 in “Endocrine Related Cancer”

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

research Epigenetic Regulation of 5α Reductase-1 Underlies Adaptive Plasticity of Reproductive Function and Pubertal Timing

8 citations , January 2022 in “BMC Biology”

Environmental factors affect reproductive traits by altering the SRD5A1 gene.

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

Male pattern baldness is likely caused by multiple genes, not just 5α-reductase genes.

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community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 139 upvotes 2 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community No fearmongering /just facts on yesterday someone posting on eye issues

in Finasteride/Dutasteride 33 upvotes 7 months ago

Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 8 months ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

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