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GlossarySteroid 5 Alpha-Reductase 1 (SRD5A1)

converts testosterone into a more potent androgen, dihydrotestosterone

Steroid 5 Alpha-Reductase 1 (SRD5A1) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

Potential Synergistic Effects of Haedoksamul-Tang and Finasteride on 5α-Reductase Inhibition and Proliferation of Human Follicle Dermal Papilla Cells

research Potential Synergistic Effects of Haedoksamul-Tang and Finasteride on 5α-Reductase Inhibition and Proliferation of Human Follicle Dermal Papilla Cells

April 2019 in “Advances in integrative medicine”

HST and HST/F promote hair growth and may help treat alopecia.

research RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells

4 citations , January 2019 in “Annals of Dermatology”

RE-ORGA, a Korean herb extract, may help prevent hair loss.

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

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community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 101 upvotes 1 year ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community Should I switch from fin to dut? (21 y/o diffuse thinner)

Hhh in General 134 upvotes 2 months ago

A 21-year-old experiencing diffuse thinning is considering switching from finasteride to dutasteride after using topical and oral minoxidil and finasteride. They have seen some regrowth but are concerned about overall density loss, especially at the crown.

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