Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

February 2012 in “ Experimental Dermatology ”

Silke Redler, Rachid Tazi-Ahnini, Dmitriy Drichel, Mary P. Birch, Felix F. Brockschmidt, K. Dobson, Kathrin A. Giehl, Melanie Refke, Nadine Kluck, Roland Kruse, Gerhard Lutz, Hans Wolff, Markus Böhm, Tim Becker, Markus M. Nöthen, Regina C. Betz, Andrew G. Messenger

steroid-5-alpha-reductase SRD5A1 SRD5A2 sex steroid hormone receptors ESR1 ESR2 PGR female pattern hair loss FPHL 5-alpha-reductase estrogen receptor 1 estrogen receptor 2 progesterone receptor

TLDR No link found between specific genes and female pattern hair loss.

This study investigated the association between certain genetic variants related to sex hormones and steroid-5-alpha-reductase genes and female pattern hair loss (FPHL). The study found no significant association between these genetic variants and FPHL, suggesting that these genes may not be involved in the development of FPHL. The study recommends future genetic studies of FPHL to include systematic genome-wide approaches.

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