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GlossarySteroid 5 Alpha-Reductase 2 (SRD5A2)

enzyme converting testosterone to potent androgen dihydrotestosterone (DHT)

Steroid 5 Alpha-Reductase 2 (also known as 5α-Reductase Type 2 or SRD5A2) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This enzyme plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and benign prostatic hyperplasia.

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research Steroidogenesis of the Testis: New Genes and Pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research Association of Childhood Dehydroepiandrosterone Sulfate Concentration, Pubertal Development, and DNA Methylation at Puberty-Related Genes

1 citations , November 2024 in “European Journal of Endocrinology”

Higher childhood DHEAS levels are linked to advanced puberty and DNA changes.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

Potential Synergistic Effects of Haedoksamul-Tang and Finasteride on 5α-Reductase Inhibition and Proliferation of Human Follicle Dermal Papilla Cells

research Potential Synergistic Effects of Haedoksamul-Tang and Finasteride on 5α-Reductase Inhibition and Proliferation of Human Follicle Dermal Papilla Cells

April 2019 in “Advances in integrative medicine”

HST and HST/F promote hair growth and may help treat alopecia.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 447 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

community Pirfenidone - The answer to fibrosis and baldness

in Treatment 18 upvotes 4 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community M44 Hairloss Trichotest and Finasteride

in Finasteride/Dutasteride 6 upvotes 2 years ago

User received Trichotest results not recommending Finasteride. They are on Oral Minoxidil 2.50 and considering adding Finasteride.

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