Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling

February 2005 in “ Endocrinology ”

Ulrich Ohnemus, Murat Uenalan, Franziska Conrad, Bori Handjiski, Lars Mecklenburg, Motonobu Nakamura, José Inzunza, Jan-Ακε Gustafsson, Ralf Paus

estrogens estrogen receptor alpha estrogen receptor beta 17beta-estradiol ER antagonist ICI 182.780 catagen telogen anagen apoptotic hair follicle keratinocytes E2 ERα ERβ

Studysummary This study found that estrogen receptor beta plays a significant role in murine hair growth control, potentially acting as a silencer of estrogen receptor alpha's catagen-promoting effects.

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