17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway

    February 2000 in “ Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism ”
    Sanjay Chanda, Carole Robinette, John F. Couse, Robert C. Smart
    TLDR Estradiol stops hair growth in mice, but an antagonist can reverse this effect.
    The study investigated the effects of 17β-estradiol and ICI-182780 on the hair follicle cycle in mice, focusing on the estrogen receptor-α pathway. Researchers found that 17β-estradiol prolonged the telogen (resting) phase of the hair cycle, while ICI-182780, an estrogen receptor antagonist, shortened it. These findings suggested that estrogen receptor-α played a significant role in regulating hair follicle cycling, with potential implications for understanding hair growth and alopecia.
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