Pubertal Hormones Increase Hippocampal Expression of α4βδ GABAA Receptors
February 2019
in “
Neuroscience letters
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that both declining levels of the neurosteroid THP and increasing levels of estradiol before puberty trigger maximal expression of α4βδ GABAA receptors in the CA1 hippocampus of female mice.
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The study concluded that pubertal hormones increased the expression of α4βδ GABAA receptors in the hippocampus, driven by rising levels of 17β-estradiol (E2) and declining levels of the neurosteroid THP. This change was mediated by estrogen receptor-α (ER-α) and was linked to alterations in anxiety, synaptic function, and potentially mood and cognitive neuropathologies. The findings provided insights into the molecular changes during puberty that could influence synaptic plasticity, learning, and anxiety.
