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GlossarySynaptic Plasticity

ability of synapses to change strength based on activity

Synaptic plasticity refers to the ability of synapses, the connections between neurons in the brain, to strengthen or weaken over time in response to increases or decreases in their activity. This process is fundamental for learning, memory, and overall brain adaptability, as it allows the neural network to reorganize and optimize its function based on experiences and new information.

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Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

10 citations, December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

research Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

March 2024 in “Journal of Neuroscience Research”

Finasteride may reduce depression and anxiety in female rats and improve brain connectivity.

research Pubertal Hormones Increase Hippocampal Expression of α4βδ GABAA Receptors

5 citations, February 2019 in “Neuroscience letters”

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

research Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

April 2024 in “Journal of psychiatric research”

Short-term finasteride use in male rats caused anxiety, depression, and memory problems.

research Sex-Dependent Responsiveness of Hippocampal Neurons to Sex Neurosteroids: A Role of Arc/Arg3.1

3 citations, January 2022 in “Journal of neuroendocrinology”

Sex hormones affect brain cells differently in males and females.

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community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 86 upvotes 7 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.