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GlossarySynaptic Plasticity

ability of synapses to change strength based on activity

Synaptic plasticity refers to the ability of synapses, the connections between neurons in the brain, to strengthen or weaken over time in response to increases or decreases in their activity. This process is fundamental for learning, memory, and overall brain adaptability, as it allows the neural network to reorganize and optimize its function based on experiences and new information.

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Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

research Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

April 2024 in “Journal of psychiatric research”

Short-term finasteride use in male rats caused anxiety, depression, and memory problems.

Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

research Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

March 2024 in “Journal of Neuroscience Research”

Finasteride may reduce depression and anxiety in female rats and improve brain connectivity.

research Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

22 citations , October 2019 in “Cerebral cortex”

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

research Different Synaptic Stimulation Patterns Influence Local Androgenic and Estrogenic Neurosteroid Availability Triggering Hippocampal Synaptic Plasticity in Male Rats

10 citations , February 2017 in “European journal of neuroscience/EJN. European journal of neuroscience”

The availability of certain hormones and specific stimulation patterns affect long-term synaptic changes in the male rat brain.

The Interaction Between Finasteride and Corticosterone Levels: Implications for Depression and Anxiety-Like Behavior and Hippocampal Synaptic Plasticity in Male Rats

research The Interaction Between Finasteride and Corticosterone Levels: Implications for Depression and Anxiety-Like Behavior and Hippocampal Synaptic Plasticity in Male Rats

May 2025 in “Psychopharmacology”

Chronic finasteride use in male rats doesn't strongly cause depression or anxiety due to adaptive stress hormone changes.

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community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 3 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 1 month ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 1 year ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.